After leaving Scrubs, Reyes guest-starred in several shows, including Castle, Medium, Off the Map, and Law & Order: Special Victims Unit. In 2011 she starred as a mother dealing with the return into her life of her estranged husband after his stint in prison in the independent drama Gun Hill Road. The film is set in Reyes' native Bronx, and its title refers to a real-life street that intersects Bainbridge Avenue on which Reyes herself grew up. The film premiered at the Sundance Film Festival. Reyes also had small supporting roles in several films, including Went to Coney Island on a Mission from God. . . Be Back by Five (1998), Bringing Out the Dead (1999), Washington Heights (2002), and Dirty (2005).
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