Gru and the Minions steal the shrink ray from a secret base in East Asia, but Vector intercepts them and steals it for himself. Gru attempts to break into Vector's impregnable fortress to recover the shrink ray, only to be defeated by numerous kinds of traps. As nothing seems to work, he notices three orphan girls, Margo, Edith, and Agnes, who are able to easily enter the base because they are selling cookies. Gru disguises himself and adopts the girls, planning to use them to infiltrate Vector's base. However, Gru has trouble nurturing them properly due to their stubbornness, their ballet classes and his own ineptitude as a parent.
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